AIM: To evaluate the efficacy and safety of compound anisodine injection combined with anti-VEGF therapy in treatment of macular edema of branch retinal vein occlusion.

METHODS: Sixty patients with retinal vein occlusion were randomly divided into the combined group and the control group. The control group was treated with a conventional anti-VEGF injection. The combined group was treated with compound anisodine and anti-VEGF injection. Treatment of compound anisodine: one injection per day, after 14d of injections pause for 14d, a total of 28 injections. Compare the therapeutic effects and safety of the two groups.

RESULTS:After anti-VEGF combined with compound anisodine and VEGF treatment, the visual acuity of the two groups were significantly increased(F_time=185.05, P_time<0.001; F_group=3.34, P_group=0.025); The CRT of the two groups were significantly decreased after treatment(F_time=286.2, P_time<0.001; F_group=12.46, P_group<0.001)and there was significantly difference between the control group and the combined group. However, there was no significant difference in visual acuity and CRT between the two groups on the 15^th day of treatment.

CONCLUSION: Compound anisodine combined with anti-VEGF therapy can improve the therapeutic effect in patients with retinal vein occlusion.