AIM:To study the effect of biological keratoconjunctivitis combined with Ganciclovir Pellicles in patients with infectious keratitis and the effect on serum levels of inflammatory factors.

METHODS: In this study, 54 patients with 54 eyes were selected as the research object and divided into the observation group and the control group according to the random number table method. All patients were treated with bioartificial corneal transplantation. The patients in the observation group were treated with Ganciclovir eye drops, and the control group was treated with Aciclovir eye drops. The changes of LogMAR visual acuity, corneal transparency, serum inflammatory factors and cytokines were analyzed.

RESULTS: The rates of getting rid of blindness in the observation group and the study group were 93% and 89% respectively(P=0.642). The LogMAR visual acuity of two groups were significantly improved in 1wk and 6mo after operation compared with that before operation(P<0.05). At 7d after operation, the levels of IL-6, TNF-α, INF- γ, SOD, NO and MDA in the two groups were significantly improved, and the improvement of the indexes in the observation group was better than that of the control group(P<0.05). The rate of adverse reaction rate between two groups showed no significant difference(P=0.556).

CONCLUSION: Biological keratoconus combined with Ganciclovir has a good effect on viral keratitis, which can improve vision, inflammation and reduce the level of MDA.