AIM: To analyze the hemostatic effect and mechanism of triamcinolone acetonide in the treatment of proliferative diabetic retinopathy(PDR).

METHODS: Totally 400 patients were treated in our hospital for PDR between January 2013 and March 2014. All subjects were divided into groups. The control group was treated with vitrectomy directly. The observation group was treated with triamcinolone acetonide at 4-14d before surgery. The differences of the indexes and complications in postoperative vision correction were compared between the two groups.

RESULTS: The expression levels of u-PA, t-PA and PAI-1 in the observation group were significantly higher than those in the control group(P<0.01). The operation time and blood loss during the observation period were significantly lower in the observation group than in the control group(P<0.01). The incidence of retinal breaks and vitreous hemorrhage in the group was significantly lower than that in the control group(P<0.05). The incidence of macular edema after the operation was significantly lower than that in the control group(P<0.01).

CONCLUSION: Vitrectomy in patients with PDR is often accompanied by hemorrhage and various complications. The use of triamcinolone acetonide can regulate the level of multiple clotting factors in the vitreous cavity of the patient, thereby reducing the amount of bleeding or directly exerting hemostasis, increasing surgical safety, reducing the incidence of complications, which is worthy of clinical application.