AIM: To observe and analyze the ocular surface parameters in patients with type 2 diabetes mellitus and/or hypertension using non-contact ocular comprehensive surface analyzer.

METHODS: Totally 160 patients were divided into four groups. And 40 patients were diagnosed with type 2 diabetes mellitus, 40 patients with hypertension, 40 patients with type 2 diabetes mellitus and hypertension, and 40 patients without type 2 diabetes mellitus and hypertension were selected from our hospital from January 2017 to December 2018. OSDI scores, tear meniscus height, eye red index, corneal fluorescein sodium staining scores, non-invasive tear film rupture time(first tear film rupture time and average tear film rupture time)were analyzed and compared among the four groups.

RESULTS: The subjective perception of eye discomfort was more obvious in patients with T2DM. Patients with T2DM and/or hypertension were more likely to have eye congestion. Compared with the patients without T2DM and hypertension, the tear meniscus height and average tear film rupture time of T2DM patients were significantly reduced(P<0.05). However, the first tear film rupture time and corneal fluorescein sodium staining score were not statistically different among the four groups(P>0.05).

CONCLUSION: Non-contact comprehensive ocular surface analyzer can observe the ocular surface characteristics of the patients non-invasively and provide relatively objective quantitative examination results. Ocular stability in patients with T2DM is lower than in patients without T2DM and hypertension, and ocular surface homeostasis of these patients is more likely to be broken.