AIM: To investigate the relationship between neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR)and type 2 diabetic retinopathy(DR).

METHODS:A total of 200 cases with type 2 diabetes mellitus were involved. All patients were divided into three groups according to the fundus examination: diabetes mellitus(DM, n=100), non-proliferative diabetic retinopathy(NPDR, n=62)and proliferative diabetic retinopathy(PDR, n=38). 100 healthy persons were selected as the normal control group(NCG, n=100). The related indicators, such as neutrophil count, lymphocyte count and platelet count were measured.

RESULTS: The value of NLR was significantly higher in PDR group patients than in NC group(1.81), DM group(1.76)and NPDR group(1.85)(P<0.05). The value of PLR was significantly higher in PDR group patients(126.18)than in DM group(111.64)(P<0.05). Logistic regression analysis showed that age(β= -0.047)was protective factor, course of diabetes(β=0.071)and systolic blood pressure(β=0.024)were risk factors for diabetic retinopathy(P<0.05), but the value of NLR and PLR was not statistically significant in the Logistic regression analysis.

CONCLUSION: The value of NLR and PLR increased in the PDR group, but it is not independent risk factor for diabetic retinopathy.