AIM: To study the effect of resveratrol on body mass and biochemical parameters of diabetic cataract model rats.

METHODS: Thirty rats were divided into blank group, model group and treatment group with 10 rats for each. Rats in the blank group were not treated. Rats in the model group and the treatment group were modeled. Rats in the treatment group were intervened with astragalol. Lens opacity, body mass, body growth and biochemical indexes of rats in each group were detected. The right eyeballs of rats in the three groups were stained with HE.

RESULTS: The rats in the blank group had transparent lens and no opacity; the degree of lens opacity and the overall score of cataract in the treatment group were better than those in the model group(P<0.05); at 3^rd and 5^th weeks, the body weight and length of the rats in the treatment group were higher than those in the model group, and the levels of FPG and 2hPG were lower than those in the model group(P<0.05); after 5wk, the biochemical indexes in the treatment group were significantly improved compared with those in the model group(P<0.05).

CONCLUSION: Astragall can improve the degree of lens opacity in diabetic cataract rats, alleviate the effect of disease on the body weight of rats, regulate the level of blood sugar and biochemical indicators in rats, and alleviate the progress of cataract.