AIM: To explore the changes of morphological parameters of corneal endothelial cell in patients with choroidal detachment following rhegmatogenous retinal detachment(RDD-CHD).

METHODS: Seventy patients(70 eyes)with RDD-CHD were collected consecutively. In patients with RDD-CHD, thirty-eight cases(38 eyes)not with high myopia were enrolled in group A; 32 cases(32 eyes)associated with high myopia were enrolled in group B. Thirty-six normal controls(36 eyes)were enrolled in group C. We measured the related morphological parameters of corneal endothelial cells in all subjects using corneal specular microscope. The parameters of corneal endothelial cells included minimum size of cell area(S_min), maximum size of cell area(S_max), average size of cell area, standard deviation of cell area(SD), coefficient of variability cell area(CV), cell density of corneal endothelial cells(CD)and hexagonality(HG).

RESULTS: There were statistically differences in the CD(P<0.001)and hexagonality(P<0.001)between the patients with RDD-CHD and normal subjects. There were statistically differences in the CD between groups A and B(P<0.05), between groups A and C(P<0.05), between groups B and C(P<0.001). SD correlated with axis length(r_s=-0.426, P<0.01); CV correlated with axis length(r_s=0.494, P<0.01), CD correlated with intraocular pressure(r_s=-0.025, P<0.05), CD correlated with axis length(r_s=0.368, P<0.05), HG correlated with course(r_s=0.552, P<0.05). In patients with RDD-CHD, SD correlated with axis length(r_s=0.236, P<0.05); CV correlated with axis length(r_s=0.159, P<0.05), HG correlated with course(r_s=0.142, P<0.05), S_max correlated with intraocular pressure(r_s=-0.314, P<0.01).

CONCLUSION: The valus of HG and CD of corneal endothelial cells in patients with RDD-CHD were both lower than that of the normal subjects. Axis length, course and intraocular pressure might influence the morphological parameters of corneal endothelium in RDD-CHD patients.