AIM: To evaluate the short-term clinical efficacy of pranoprofen eye drops combined with sodium hyaluronate eye drops in the treatment of moderate to severe dry eye and its influence on the psychological status of patients.

METHODS: From January to December 2018, 318 patients with moderate to severe dry eye were selected and treated in ophthalmology department of our hospital. The patients were divided into experimental group(238 patients)and control group(80 patients)by random number table method, and the control group was treated with sodium hyaluronate eye drops, while the test group was treated with pranoprofen eye drops combined with sodium hyaluronate eye drops. The general data of the patients were statistically analyzed. Before treatment, 7d, 14d, 28d after treatment, the patients' scores of conscious symptoms and signs were investigated by questionnaire, the degree of conjunctival congestion, tear breakup time, corneal fluorescein staining and tear secretion were examined, and the degree of anxiety and depression were evaluated.

RESULTS: There was no significant difference in general data between the two groups(P>0.05). In terms of patients' scores of conscious symptoms and signs, degree of conjunctival congestion, tear breakup time, corneal fluorescein staining and tear secretion, the experimental group was significantly improved 7d after treatment, and the effect was more significant with the prolonged treatment, while the control group was gradually improved 14 or 28d after treatment. At the same treatment time point, the efficacy of the experimental group was significantly better than that of the control group, and the difference was statistically significant(P<0.05). With the improvement of the condition after treatment, the anxiety or depression symptoms of the patients were improved. The experimental group was significantly improved 7d after treatment, while the control group was gradually improved 14d or 28d after treatment. At the same treatment time point, compared with the control group,the anxiety and depression degree of the patients in the experimental group were significantly reduced(P<0.05).

CONCLUSION: Pranoprofen eye drops combined with sodium hyaluronate eye drops for treatment of dry eye syndrome had fast and significant effect, patients' self-consciousness symptoms and signs are significantly improved, conjunctival congestion and corneal fluorescein staining are reduced, tear breakup time is prolonged, tear secretion is increased, and anxiety or depression are significantly improved.