AIM: To explore the clinical study of Fuming tablet combined with timolol maleate eye drops in the treatment of open angle glaucoma.

METHODS: Totally 82(147 eyes)patients with open angle glaucoma who were treated in our hospital from April 2017 to July 2018 were selected as the research objects. According to the treatment methods, they were divided into control group and observation group, 41 cases in each group. Patients in the control group(72 eyes)were treated with timolol lecitrate eye drops, while patients in the observation group(75 eyes)were treated with Fuming tablets on the basis of the control group. The clinical efficacy of the two groups was observed. The intraocular pressure and hemorheology of the patients in the two groups were compared and analyzed before and after treatment.

RESULTS: After 12wk treatment, there was a significant difference in the total clinical effective rate(94.7% vs 80.6%)between the observation group and the control group(P<0.05). And the intraocular pressure of both groups was significantly lower than that before and after 6wk of treatment(P<0.05), and the intraocular pressure of the observation group was significantly lower than that of the control group(P<0.05). The levels of PSV, EDV and RI in the control group were not significantly different from those before treatment(P>0.05); while the levels of PSV and EDV in the observation group were significantly higher than those before treatment(P<0.05), and the levels of RI were significantly lower than those before treatment(P<0.05). And there were significant differences in the levels of PSV, EDV and RI between two groups(P<0.05). There was no significant difference in the total incidence of adverse reactions between two groups during the treatment(P>0.05).

CONCLUSION:Fuming tablet combined with timolol maleate eye drops can effectively improve the clinical efficacy of patients with open angle glaucoma. The effect of lowering intraocular pressure is obvious. At the same time, it has a good effect on the ocular hemorheology of patients with open angle glaucoma. This is a safe and reliable clinical treatment of open angle glaucoma.