The invasion of the cornea by capillary or lymphatic vessels leads to corneal neovascularization and if not handled in time, it will seriously affect vision, the establishment and application of transgenic mouse models of corneal neovascularization provides a good platform for the study of corneal neovascularization mechanism, the screening of antiangiogenic drugs and the evaluation of treatments. Transgenic mouse model of corneal neovascularization is a very valuable and potential animal model. This paper mainly introduces the application of transgenic mouse models in the research of corneal neovascularization.