Corneal disease is one of the main ophthalmopathy that may lead to blindness in China. Infectious keratitis is the main cause of corneal blindness. For corneal infections that are difficult to control by drugs, corneal transplantation is the only hope to control the infection and restore the sight. However, the demand for suitable donor corneas is increasing much faster than the number of donors, leaving thousands of curable patients untreated and even lose their eyeballs. Thus, it's urgent to seeking new biomaterials for corneal donor. In recent years, there have come forward great progress in bioengineering cornea. Here, we reviews its application present in clinic and prospects for the future, exploring the feasibility of bioengineering cornea being the replacement of human corneal donor in corneal transplantation.