AIM: To quantitatively compare the effects of different surface treatments and designs of intraocular lens(IOL)on posterior capsule opacification(PCO)using EPCO2000.

METHODS: A retrospective study was conducted to observe 600(971 eyes)age-related cataract patients after 1a of phacoemulsification with implantation of intraocular lens in our hospital from March to November 2016. Patients were divided into 4 groups based on the type of IOL implant: 43 eyes in ZCB00 group, 365 eyes in ZA9003 group, 340 eyes in HQ-201HEP group and 223 eyes in Human Optics group. Retroillumination slit-lamp photographs were taken after the pupil was fully dilated and the degree of PCO was scored by EPCO2000 and compared among the groups.

RESULTS: There were 167 eyes(17.2%)with PCO involving the central 3mm of the pupil and 78 eyes(8.0%)with significant PCO or Nd:YAG laser capsulotomy. According to the hydrophobicity of IOL optical surface materials, the total score of hydrophobic group 0.000(0.000, 0.012)was obviously lower than that of hydrophilic group 0.127(0.056, 0.242)(P<0.05). The total score of heparin-free group 0.127(0.056, 0.242)was lower than that of heparin-modified group 0.175(0.067, 0.371), and the difference was statistically significant(P<0.05). The total score of single-piece group 0.000(0.000, 0.012)was obviously lower than that of three-piece group 0.120(0.041, 0.247)(P<0.05). According to the different haptic angular magnitude of IOL, the total score of the 0° haptic anglulation group 0.107(0.000, 0.212)was lower than that of the 5° haptic anglulation group 0.142(0.051, 0.298), and the difference was statistically significant(P<0.05).

CONCLUSION: A single-piece, square-edged, hydrophobic acrylic IOL can reduce PCO formation more effectively.