AIM:To investigate the effect of internal limiting membrane(ILM)transplantation in the treatment of large macular hole.

METHODS: Totally 35 patients with large macular hole(>700μm)underwent vitrectomy in our hospital from March 2016 to March 2018 were retrospectively analyzed, in which group A(17 patients)underwent vitrectomy and internal limiting membrane peeling generally, group B(18 patients)underwent vitrectomy and internal limiting membrane transplantation. The best corrected visual acuity(BCVA)and macular hole closure rate were performed preoperative and 3mo postoperative.

RESULTS: The macular hole closure rate in group A was 65% at 3mo safter surgery, and macular hole closure rate in group B was 100% at 3mo after surgery(P<0.05). The rate of BCVA of A group which were significantly improved at 3mo postoperative(increase by 2 lines or more)compared preoperative is 35%, and the rate of BCVA of B group is 78%(P<0.05).

CONCLUSION: Internal limiting membrane transplantation can improve the closure rate of large macular hole and visual function after surgery in a certain extent. It is a safe and effective surgical method.