AIM: To discuss the clinical efficacy of tobramycin dexamethasone eye ointment combined with OCuSOFT tea tree oil cleaning wipes in the treatment demodex blepharitis.

METHODS: Prospective clinical study. Totally 72 patients with demodex blepharitis were selected. They were randomly divided into three groups. The experimental group was treated with tobramycin dexamethasone eye ointment combined with OCuSOFT tea tree oil cleaning wipes. After 30d of treatment, the symptom score, the number of eyelash mites and the score of clinical signs were observed under slit lamp. The data before and after treatment were compared by paired sample t-test and analysis of variance.

RESULTS: There was significant difference in demodex count among the three groups before and after treatment(P<0.01). The difference of total symptom score was statistically significant(F=20.05, P<0.01). The difference of total score of physical signs was statistically significant(F=8.10, P<0.01).

CONCLUSION: Tobramycin dexamethasone eye ointment combined with OCuSOFT tea tree oil cleaning wipes is effective in the treatment of demodex blepharitis. Tea tree oil cleaning wipes are portable,easy to preserve and not easy to deteriorate.