AIM: To investigate the changes of serum cytokines in patients with polypoid chorioretinopathy and analyze its risk factors.

METHODS: Select 50 cases of PCV patients in our hospital from December 2018 to May 2019 served as observation group, 50 cases of senile cataract patients who want to undergo cataract surgery served as control group. The levels of inflammatory factors and angiogenic factors were compared between the two groups, and the general clinical data were analyzed by single factor and logistic regression.

RESULTS: The levels of IL-8, MCP-1, VEGF and PEDF in the observation group were significantly higher than those in the control group(P<0.01). The results of ANOVA showed that there was significant difference between smoking history and hypertension between the two groups(P<0.05); Logistic regression analysis showed that the increased levels of IL-8, MCP-1, VEGF, PEDF, smoking history and hypertension were independent risk factors for PCV.

CONCLUSION: The serum levels of IL-8, MCP-1, VEGF and PEDF in PCV patients were all increased abnormally, which was closely related to smoking history and hypertension.