AIM: To evaluate the effectiveness and surgical timing for the treatment of lacrimal duct obstruction secondary to chemotherapy by bicanalicular stent intubation.

METHODS:A retrospective analysis was performed on 50 patients of 100 eyes who underwent bicanalicular stent intubation from July 2015 to April 2018 in our hospital, all the patients were suffered from lacrimal duct obstruction secondary to chemotherapy. They were divided into three groups according to the length of time between the date of surgery and the date of first chemotherapy. All patients were followed for at least 12mo post-operation. Ophthalmic physical examinations and lacrimal duct irrigations were recorded.

RESULTS: Evaluating the effectiveness 12mo after surgery. The efficiency of group 1, group 2 and group 3 were 83.3%, 61.1%, 30.0%, respectively. With the delay of surgical intervention, the efficiency decreased significantly, and the difference was statistically significant(χ²=18.322, P<0.01).

CONCLUSION: Early diagnosis and surgical intervention of lacrimal duct obstruction secondary to chemotherapy with 5-FU, S-1 or docetaxel in patients with malignant tumors are of great significance to improve the success rate of surgery.