颈内动脉狭窄患者的脉络膜厚度和脉管指数的改变
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Changes of choroidal thickness and vascular index in patients with internal carotid artery stenosis
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    摘要:

    目的:使用扫频光相干断层扫描(SS-OCT)比较无眼部症状的颈内动脉狭窄(ICAS)患者和健康人之间黄斑区脉络膜厚度(SFCT)和脉管指数(CVI)。

    方法:回顾性研究。纳入2018-03/2019-06我院神经外科确诊ICAS患者40例,取其与颈内动脉狭窄同侧的40眼为ICAS组,另外纳入20例性别年龄相匹配的健康人的双眼作为对照组。所有受试者均于同一时间段用SS-OCT行黄斑扫描,测量SFCT,并将OCT图像以Image J软件二值化处理测量中心凹3mm范围脉络膜的CVI。

    结果:ICAS组和对照组的SFCT分别为208±66、234±77μm(P=0.27)。ICAS组和对照组的CVI值分别为64.5%±1.7%和66.1%±2.7%(P=0.04)。受试者工作曲线(ROC curve)中CVI的曲线下面积(AUC)为0.76(P=0.005),而SFCT的AUC为0.58(P=0.41)。

    结论:无眼部症状的ICAS患者CVI低于正常对照组,而SFCT无明显改变,提示对无眼部症状的ICAS患者检测其CVI较SFCT更有助于早期的发现脉络膜血液循环的改变。

    Abstract:

    AIM: To compare the macular subfoveal choroidal thickness(SFCT)and choroidal vascular index(CVI)between the patients with internal carotid artery stenosis(ICAS)but without ocular symptoms and controlled healthy people.

    METHODS: This is a retrospective comparative study. Forty eyes(grouped as ICAS group)from 40 ICAS patients and 40 eyes(grouped as control group)from 20 matched healthy people were included in this study. All included eyes were received OCT scanning to measure the SFCT. And OCT images were binarized with Image J software to measure CVI values. These values were compared between the two groups.

    RESULTS: SFCT of ICAS group and control group were 208±66μm and 234±77μm respectively, with no statistical difference between the two groups(P=0.27). The CVI of ICAS group(64.5%±1.7%)was significantly lower compared with that of control group's(66.1%±2.7%)(P=0.04). The area under the curve(AUC)of CVI in the ROC curve was 0.76 (P=0.005), while the AUC of SFCT was 0.58(P=0.41).

    CONCLUSION: It is suggested that compared with the detection of SFCT, the detection of CVI is more helpful to the early discovering of the changes of choroidal circulation in this kind of patients.

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刘然,晏颖,陈晓.颈内动脉狭窄患者的脉络膜厚度和脉管指数的改变.国际眼科杂志, 2020,20(3):533-536.

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  • 收稿日期:2019-11-08
  • 最后修改日期:2020-02-19
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  • 在线发布日期: 2020-03-13
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