AIM: To observe the clinical effect of 25G vitrectomy combined with inner limiting membrane(ILM)peeling in the treatment of severe proliferative diabetic retinopathy(PDR)with macular displacement.

METHODS: Clinical data of 36 cases(36 eyes), diagnosed as severe proliferative diabetic retinopathy with macular displacement in Jiangsu Province Hospital were collected. Eighteen cases admitted from January to December 2016 were included in the control group(18 eyes, treated by 25G vitrectomy), while 18 cases admitted from January to December 2017 were included in the combined group(18 eyes, treated by 25G vitrectomy with ILM peeling). Best corrected visual acuity(BCVA), intraocular pressure(IOP), complications, and the thickness of macular center area(CMT)were examined during follow-up at 7d, 1mo, 3mo and 6mo postoperative.

RESULTS: BCVA showed a significant improvement at postoperative 6mo compared with baseline in both groups (P<0.05). CMT of the combination group was thinner than that of the control group(P<0.001). Two eyes(11%)had intraocular hypertension,and 1 eye(6%)had macular edema in the combined group, while post-operative complications included intraocular hypertension(6%),macular membrane(6%)and vitreous hemorrhage(6%)in the control group. No statistical difference was found in the complication rates between the two groups(all P=1.000).

CONCLUSION: In the treatment of severe PDR with macular displacement, 25G vitrectomy combined with ILM peeling can effectively and safely improve visual acuity and reduce the thickness of macular center area.