AIM: To evaluate the efficacy and safety of ultrasound cycloplasty(UCP)in the treatment of neovascular glaucoma(NVG).

METHODS: Thirty patients(30 eyes)with NVG who were treated with UCP at our hospital from January 2018 to December 2018 were collected. All patients received comprehensive ophthalmic examination. Visual acuity, best corrected visual acuity(BCVA), intraocular pressure(IOP), pain grade score, ocular surface, number of glaucoma drugs and complications were recorded before and 1, 3d, 1wk and 1, 2, 3, 6mo after operation, and the efficacy and safety were evaluated.

RESULTS: The postoperative visual acuity was improved, the pain score was decreased, and the use of intraocular pressure-lowering drugs was decreased and the IOP decreased significantly(P<0.01). The preoperation visual acuity, pain score, use of intraocular pressure-lowering drugs and IOP was \〖1.63±0.59(LogMAR)\〗, \〖2(1,4)\〗, \〖4(4,4)\〗 and(44.19±13.72)mmHg. The postoperative IOP were decreased at different observation time within 6mo, and the differences with preoperative IOP were statistically significant(all P<0.01). The IOP decrease rates were 57.32%, 56.45%, 56.82%, 55.64%, 52.37%, 50.20% and 49.18% on 1d, 3d, 1wk, 1mo, 2mo, 3mo and 6mo after surgery respectively. On 6mo after treatment, 8 eyes(31%)IOP were complete controlled, 7 eyes(27%)were partially controlled, 11 eyes(42%)cannot be controlled, and 4 eyes were lost to follow-up. The IOP reduction on 6mo of postoperation was significantly correlated with that of preoperation(r=0.928, P<0.001). The number of glaucoma drugs and pain scores were decreased, and the differences with that of preoperation were statistically significant(P<0.01), and the BCVA were improved, the differences were statistically significant(P<0.01). There was no serious complications were occurred in all patients after operation.

CONCLUSION: UCP is high safety and few complications for NVG treatment. It has significant effect on reducing IOP, relieving ocular pain. The higher the preoperation IOP, the greater the IOP reduction after surgery. It was a promising anti-glaucoma method.