AIM: To observe the high-order aberrations, diopters, ocular structural parameters and their correlation in adolescents with high myopia.

METHODS: Cross sectional study. Totally 116 adolescent high myopia patients(116 eyes)were selected from the Center of Optometry of the First Affiliated Hospital of Harbin Medical University on July 9, 2019. The axial length and intraocular pressure were measured. The high-order aberrations(RMSg, RMSh, Z22, Z33, Z31,Z40,RMS3-RMS7), corneal curvature(minimum K1, maximum K2, average km), central cornea thickness(CCT), anterior chamber depth(ACD)and anterior chamber angle(ACA)were measured with Sirius three-dimensional anterior segment analyzer. The correlation between the above eye parameters was analyzed.

RESULTS: There was a significant negative correlation between diopter and axial length(r= -0.400, P<0.001); a positive correlation between axial length and anterior chamber depth(r= 0.433, P<0.05), a negative correlation between axial length and corneal curvature(K1, K2, Km)(P<0.05); a negative correlation between total higher-order aberrations and diopter(r=-0.189, P<0.05), which was negatively correlated with the axial length(r=-0.228, P<0.05). There was no correlation between the higher-order aberrations and the sphericity(P>0.05), Z40 was positively correlated with the corneal curvature(K1, K2, Km)(P<0.05), and no correlation between higher-order aberrations and CCT, ACD, ACA was found.

CONCLUSION: With the increase of myopia degree, the axial length and total higher-order aberrations of adolescent high myopia increase, and the total higher-order aberrations are negatively correlated with the axial length. The increase of axial length may be a compensatory way to reduce the high-order aberrations and promote the development of myopia.