超声乳化术对小梁切除术患者眼压及滤过泡功能的影响
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Effect of phacoemulsification on intraocular pressure and bleb function in eyes with previous trabeculectomy
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    摘要:

    目的:观察使用丝裂霉素C小梁切除术成功/合格史的患者超声乳化术后眼压(IOP)控制及滤过泡功能。

    方法:回顾性队列研究。收集2013-01-01/2015-12-31期间接受小梁切除术并随后进行白内障手术患者的数据。所有患者都曾成功/合格地进行过小梁切除术。他们通过透明角膜切口进行了简单的超声乳化手术。用Goldmann眼压计进行术后眼压随访,复查滤过泡情况。观察术后IOP控制、视力改善、抗青光眼药物的数量以及从小梁切除术到超声乳化术的时间,并与对照组进行比较。

    结果:共13例15眼患者满足了研究标准,并且在小梁切除术后进行了简单的超声乳化术。其中2眼为继发性青光眼,13眼为原发性青光眼。所有的超声乳化术均在小梁切除术后至少6mo进行(平均14.7±4.3mo)。白内障术前仅1眼(6.7%)需要抗青光眼药物治疗,超声乳化术1a后,增加到4眼(26.7%),超声乳化术2a后,进一步增加到8眼(53.3%)。术后2a所需抗青光眼药水的数量在2~4种之间。在15眼中,白内障术前(平均13.4±2.9 mmHg)与超声乳化术后1a(平均14.1±3.2 mmHg,P=0.357)和2a(平均15.1±3.3 mmHg,P=0.212)的IOP控制无显著性差异。然而,术前平均LogMAR视力为1.52±1.00, 术后平均视力为0.53±0.54,超声乳化术后的视力改善是显著的(P=0.000)。

    结论:结果显示,在不影响眼压控制的情况下,小梁切除术后白内障患者的视力明显改善。然而,手术后,特别是白内障手术后2a,抗青光眼眼药水的使用数量增加,证明了术后滤过泡功能的降低。白内障超声乳化手术后,患者应该被告知重新开始服用抗青光眼药物的可能性。白内障和青光眼手术的时机和顺序应优化,以获得最佳的手术效果。

    Abstract:

    AIM: To observe the intraocular pressure(IOP)control and bleb function after phacoemulsification in patients with previous history of successful/qualified success mitomycin-C augmented trabeculectomy.

    METHODS: This was a retrospective cohort study. Data of patients who had undergone trabeculectomy between 1st January 2013 to 31st Dec 2015 with subsequent cataract surgery were extracted from server. All patients had previous either success/qualified success trabeculectomy done. They went through uncomplicated phacoemulsification via clear corneal incision. Postoperative follow-up, review of bleb and IOP readings using Goldmann tonometer were taken. Details that were investigated include postoperative IOP control, visual improvement, number of anti-glaucoma medications, as well as the timing from trabeculectomy to phacoemulsification. Comparison with control group was made.

    RESULTS: Fifteen eyes from thirteen patients fulfilled the criteria for study and had undergone uncomplicated phacoemulsification on a post-trabeculectomy eye. Two of the eyes had secondary glaucoma while the other thirteen had primary glaucoma. All phacoemulsifications were done at least 6mo after trabeculectomy(mean 14.7±4.3mo). There was only 1 eye(6.7%)requiring anti-glaucoma medications before the cataract surgery. This number increased to 4(26.7%)at 1-year post-phacoemulsification. The number further increased to eight(53.3%)at 2y post-phacoemulsification. The number of anti-glaucoma drops needed after surgery at 2y ranged from 2-4. In all the 15 eyes, there was no statistically significant change in IOP control between pre-cataract surgery(mean 13.4±2.9 mmHg)compared to 1y(mean 14.1±3.2 mmHg, P=0.357)and 2y(mean 15.1±3.3 mmHg, P=0.212)post-phacoemulsification. Visual improvement after phacoemulsification however is significant, from a preoperative average visual acuity of LogMAR 1.52±1.00 to a postoperative average visual acuity of 0.53±0.54(P=0.000, paired t-test).

    CONCLUSION: This analysis shows significant visual improvement following cataract surgery in post-trabeculectomy patients without compromising IOP control. However, a reduced bleb function is noted following the surgery evidenced by the increase in number of anti-glaucoma drops used after surgery especially two years after the cataract surgery. Patients should be counselled regarding the possibility of restarting on anti-glaucoma medications post-phacoemulsification. The timing and sequence of cataract and glaucoma surgery should be optimized for best outcome.

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Chong JC, Teh SS, Kamaruddin H, Ong PY, Iqbal T. Effect of phacoemulsification on intraocular pressure and bleb function in eyes with previous trabeculectomy. Guoji Yanke Zazhi(Int Eye Sci) 2020;20(6): 927-933

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  • 收稿日期:2019-11-19
  • 最后修改日期:2020-03-24
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  • 在线发布日期: 2020-05-25
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