AIM: To observe the efficacy and safety of low-dose atropine eye drops combined with orthokeratology in the treatment of low and moderate myopia in adolescents.

METHODS: Totally 126 cases of low and moderate myopia in adolescents(all right eye data, 126 eyes)who all wore orthokeratology lens for 1mo were selected from May 2016 to Aug 2018. Then they were randomly divided into the experimental group and the control group. The experimental group(63 eyes)was combined with low-dose(0.01%)atropine eye drops once a night, and the control group(63 eyes)was combined with polyethyleneglycol eye drops once a night. Their AL,SE, BCNVA,PD,AMP,BUT and IOP were observed.

RESULTS: After 1y of treatment, the AL in the low myopia experimental group increased(0.13±0.03mm), while the low myopia control group increased(0.22±0.05mm). The AL in the moderate myopia experimental group increased(0.12±0.03mm),while the moderate myopia control group increased(0.20±0.05mm). The SE in the low myopia experimental group increased(0.16±0.07D), while the low myopia control group increased(0.21±0.08D). The SE in the moderate myopia experimental group increased(0.16±0.05D), while the moderate myopia control group increased(0.20±0.09D). There was statistical difference in AL and SE between the two groups(P<0.05). After 1a of treatment, there was no statistical difference in BCNVA(LogMAR), BUT and IOP between the experimental group and the control group(P>0.05). But the pupil diameter of the experimental group was significantly larger than that of the control group. The accommodation amplitude of the experimental group was lower than that of the control group(P<0.05).

CONCLUSION: 0.01% atropine eye drops combined with orthokeratology can control the progression of myopia in adolescents more effectively, which is safe and effective.