AIM: To research the correlation between the concentrations of interleukin-6(IL-6)and monocyte chemokine-1(MCP-1)in aqueous humor and the intravitreal ranibizumab injection was injected into the glass body cavity.

METHODS: Forty patients(40 eyes)diagnosed with RVO macular edema were selected as the treatment group, twenty patients(20 eyes)underwent cataract surgery were selected as the control group, anterior aqueous humor was collected before surgery in the treatment group and control group. Using the cytometric bead array methods detection the concentration of MCP-1 and IL-6. Comparison and analysis the concentration of MCP-1 and IL-6 before the operation treatment group and control group, comparison and analysis the concentration of MCP-1 and IL-6, BCVA, CMT before and after the operation in the treatment group.

RESULTS: The concentration of MCP-1(49.84±16.16、547.75±108.45pg/mL)and IL-6 in the treatment group was higher than the control group(10.71±7.26、235.65±34.45pg/mL,all P<0.001)before the operation. There was a positive correlation between the concentration of MCP-1, IL-6 and CMT before the operation in the treatment group(r=0.646, 0.912, all P<0.001). The concentration of IL-6 was significantly correlated with MCP-1(r=0.902, P<0.001). The treatment group underwent the intravitreal ranibizumab injection was injected into the glass body cavity, the concentration of IL-6, MCP-1(20.08±11.56、228.35±70.69pg/mL)was lower than before. BCVA was improved significantly compared with before operation, CMT decreased after surgery compared to before surgery(P<0.001).

CONCLUSION: There was a positive correlation between the concentration of MCP-1, IL-6 and CMT, with IVR treatment of secondary macular edema to RVO, to reduce the concentration of MCP-1 and IL-6, to reduce CMT, and reduce macular edema, improved patient's vision level.