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引用:吴燕妮,张琪.糖尿病患者角膜上皮损伤愈合延迟的研究进展.国际眼科杂志 2020;20(8):1367-1370,doi:10.3980/j.issn.1672-5123.2020.8.15
糖尿病患者角膜上皮损伤愈合延迟的研究进展
Recent advances in research on delayed corneal epithelial wound healing in diabetes
投稿时间:2019-12-04  修订日期:2020-06-28
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DOI:10.3980/j.issn.1672-5123.2020.8.15
关键词:  糖尿病  角膜上皮  愈合延迟
Key Words:  diabetes mellitus  corneal epithelium  delayed wound healing
基金项目:重庆市科卫联合医学科研项目(No.2019MSXM003); 重庆市自然科学基金面上项目(基础研究与前沿探索)(No.cstc2019jcyj-msxmX0398)
Fund Project:Joint Project of Health Bureau with Science and Technology Bureau of Chongqing(No.2019MSXM003); Basic Research program of Chongqing Natural Science Foundation Project(No.cstc2019jcyj-msxmX0398)
     
作者单位
吴燕妮 中国重庆市,重庆医科大学附属第一医院眼科
张琪 中国重庆市,重庆医科大学附属第一医院眼科
     
AuthorInstitution
Yan-Ni Wu Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University, Chongqing , China
Qi Zhang Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University, Chongqing , China
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糖尿病患者角膜上皮损伤后愈合延迟较常见,持续不愈合的角膜损伤可导致复发性上皮糜烂、角膜溃疡甚至角膜穿孔,影响视功能。本文就糖尿病患者角膜上皮损伤愈合延迟的病理基础、发病机制以及相关治疗的研究进展做一综述。概述了糖尿病患者角膜上皮结构和功能的改变,阐述了高糖、蛋白酶、泪膜、生长因子和细胞因子、角膜神经以及microRNA等在发病机制中的作用,总结了治疗糖尿病患者角膜上皮损伤愈合延迟的最新思路。

Abstract:
      Delayed healing of diabetic corneal epithelial wound is a commonly encountered condition, and persistent corneal epithelial defects may give rise to recurrent epithelium erosion, corneal ulceration, and subsequent perforation as well as affecting visual loss. The current review focused on the pathological basis, updates of the pathogenesis, and recent advances in the treatment of delayed healing of diabetic corneal epithelial wounds, wherein the roles of hyperglycemia, tear film, proteases, cytokines, corneal nerves and genes were elaborated, and the latest views on treatment strategies, for the delayed healing were summarized as well. Recent advances in research on delayed corneal epithelial wound healing in diabetes mellitus.
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