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引用:严凯,刘意,田慧丽.维生素D受体基因多态性与2型糖尿病患者视网膜病变的相关性分析.国际眼科杂志 2020;20(8):1405-1408,doi:10.3980/j.issn.1672-5123.2020.8.23
维生素D受体基因多态性与2型糖尿病患者视网膜病变的相关性分析
The relationship between vitamin D receptor gene polymorphism and retinopathy in type 2 diabetic patients
投稿时间:2019-12-02  修订日期:2020-07-09
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DOI:10.3980/j.issn.1672-5123.2020.8.23
关键词:  维生素D受体  基因多态性  2型糖尿病  视网膜病变
Key Words:  vitamin D receptor  gene polymorphism  type 2 diabetes  retinopathy
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作者单位
严凯 中国河南省平顶山市,平顶山工业职业技术学院
刘意 中国河南省郑州市,郑州铁路职业技术学院
田慧丽 中国河南省平顶山市残疾人联合会低视力康复中心眼科
        
AuthorInstitution
Kai Yan Pingdingshan Polytechnic College, Pingdingshan , Henan Province, China
Yi Liu Zhengzhou Railway Vocational & Technical College, Zhengzhou , Henan Province, China
Hui-Li Tian Department of Ophthalmology, Pingdingshan Disabled Persons' Federation Low Vision Rehabilitation Center, Pingdingshan , Henan Province, China
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目的:探讨维生素D受体基因多态性与2型糖尿病(T2DM)患者视网膜病变的相关性。

     方法:筛选2018-02/2019-01我院收治的T2DM患者198例作为研究对象,分为糖尿病性视网膜病变(DR)组(n=108)和非DR组(n=90)。应用聚合酶链反应-限制性片段长度多态性对rs1544410、rs2228570位点多态性进行检测。非条件Logistic回归分析rs1544410、rs2228570基因多态性与2型糖尿病患者视网膜病变的关系。

     结果:DR组VDR基因rs1544410位点T等位基因频率、rs2228570位点A等位基因频率均显著高于非DR组(P<0.05); CC基因型130例,CT基因型52例,TT基因型16例,CC基因型与CT+TT基因型相关指标比较有差异(P<0.05); GG基因型121例,GA基因型59例,AA基因型18例,GG基因型与GA+AA基因型相关指标比较有差异(P<0.05); BsmI基因CT+TT基因型、FokI基因GA+AA基因型是DR的危险因素(P<0.05)。

     结论:VDR基因BsmI、FokI多态性与2型糖尿病视网膜病变显著相关,可能是2型糖尿病视网膜病变的易感基因位点。

Abstract:
      AIM: To investigate the relationship between vitamin D receptor gene polymorphism and retinopathy in patients with type 2 diabetes mellitus.

     METHODS: Totally 198 T2DM patients admitted to our hospital from February 2018 to January 2019 were selected as the study objects and divided into DR group(n=108)and non DR group(n=90). The polymorphisms of rs1544410 and rs2228570 were detected by PCR restriction fragment length polymorphism. The relationship between rs1544410, rs2228570 gene polymorphism and retinopathy in type 2 diabetic patients was analyzed by unconditional Logistic regression.

     RESULTS: The frequencies of T allele at rs1544410 and A allele at rs2228570 in DR group were significantly higher than those in non DR group(P<0.05). There were 130 cases of CC genotype, 52 cases of CT genotype, 16 cases of TT genotype, and there were statistical differences between CC genotype and CT+TT genotype(P<0.05); 121 cases of GG genotype, 59 cases of GA genotype,18 cases of AA genotype, and there were statistical differences between GG genotype and GA+AA genotype(P<0.05); CT+TT genotype of BSMI gene and GA+AA genotype of FokI gene were risk factors of DR(P<0.05).

     CONCLUSION: The polymorphism of VDR gene BSMI and FokI is significantly related to type 2 diabetic retinopathy, which may be the susceptible gene locus of type 2 diabetic retinopathy.

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