Diabetic retinopathy(DR)is a kind of multi-factor mediated diseases, currently accepted DR environment that is caused by chronic high blood glucose metabolic abnormalities caused by, but it is regulated by the genetic factors, is considered to be a classic case of complex diseases, can be attributed to genetic factors, environmental factors and the interaction of the results. Genetic studies on the occurrence and development of DR have achieved some results, but the specific pathogenic genes and their pathogenesis are still not clear. In this study, potential DR susceptibility genes and their polymorphisms have been identified so far, so as to provide reference for further study of DR pathogenic genes and their pathogenesis.