目的：应用频域光学相干断层扫描仪(SD-OCT)测量糖尿病视网膜病变(diabetic retinopathy，DR)患者黄斑中心凹下脉络膜厚度(SFCT)，观察SFCT的变化，探讨SFCT与糖尿病以及糖尿病引起的视网膜病变的关系。

方法：收集152例2型糖尿病(T2DM)患者，根据患者眼底情况进行分组，NDR组72例，DR组80例，收集同时期的85例健康体检者作为对照组。后续根据DR临床分期，其中DR组分为轻度NPDR、中度NPDR、重度NPDR和PDR。参照联合国世界卫生组织对年龄的分段分为18～44岁(青年组)、45～59岁(中年组)、60～75岁(老年组)三个年龄段。分析比较各组之间的SFCT。

结果：T2DM组、对照组不同性别SFCT比较无差异(P>0.05)。T2DM组、NDR组SFCT与年龄、病程无明显相关性(P>0.05)； 对照组的SFCT与年龄呈负相关(P<0.05)。对照组老年组SFCT较中年组、青年组薄(P<0.05)，青、中年组SFCT比较无差异(P>0.05)。T2DM组SFCT较对照组薄(P<0.001)，NDR组、DR组SFCT较对照组薄(P<0.001)； DR各级的SFCT差异有统计学意义(P<0.001)。

结论：年龄是影响SFCT的相关因素，糖尿病患者SFCT较正常人变薄，随着DR病变严重程度增加SFCT会有所增厚。

METHODS: A total of 152 patients with type 2 diabetes(T2DM)were collected and grouped according to their fundus conditions. There were 72 cases in the NDR group and 80 cases in the DR group. Eighty-five healthy subjects were used as the control group. Follow-up according to the clinical stage of DR, where the DR components were mild NPDR, moderate NPDR, severe NPDR and PDR. According to the United Nations World Health Organization, the age group was divided into three age groups: 18-44 years old(youth group), 45-59 years old(middle-aged group), and 60-75 years old(old group). Analyzed and compared the SFCT between each group.

RESULTS:There was no statistically significant difference in SFCT between the T2DM group and the control group(P>0.05). The SFCT of the all group was not significantly correlated with age and course of disease(P>0.05); the SFCT of the control group was negatively correlated with age(P<0.05), and the SFCT of the elderly group was thinner than that of the middle-aged group and the young group(P<0.05). There was no significant difference between young and middle-aged(P>0.05). The SFCT of the T2DM group was thinner than the control group(P<0.001), and the SFCT of the NDR group and the DR group were thinner than the control group(P<0.001); the difference in SFCT between DR staging was statistically significant(P<0.001).

CONCLUSION: Age is a related factor that affects SFCT. Diabetic SFCT becomes thinner than normal people, and SFCT thickens with the severity of DR lesions.