方法：前瞻性研究。对2019-07/08在嘉兴市中医医院眼科需做24h眼压的患者24例48眼，使用手持型眼压计(iCare-PRO回弹式眼压计)连续48h进行2次24h眼压测量，时点分别为7：00、10：00、14：00、18：00、22：00、02：00、05：00。其中在22：00、02：00、05：00三个时间点，分别测量坐位及卧位的眼压，先进行卧位测量，之后要求患者保持坐位10min，再次测量一次眼压。重复测量用组内相关系数(ICC)来分析一致性，夜间不同体位的眼压以配对样本t检验分析比较测量结果。

结果：各时点的ICC值在0.79～0.94波动，大部分在0.90左右，双眼基本一致。夜间卧位的ICC值在0.73～0.91波动，大部分是0.86以上。各时点的ICC均在0.75以上，大部分在0.90左右，表明各时点眼压重复测量的一致性较好。但是夜间眼压波动的ICC结果较差，右眼夜间坐位波动的ICC为0.49，左眼夜间坐位为0.55； 夜间卧位右眼为0.40，左眼为0.43，右眼的一致性较差。而夜间卧位眼压均高于坐位眼压，各时点均有差异。

结论：单次的24h眼压测量可能不能高度再现，尤其是眼压波动，一次测量的结果可靠性有待研究，且夜间采取坐位测量眼压，或许不能代表实际夜间睡眠时的眼压。

METHODS: A prospective study. A handheld tonometer(iCare-PRO rebound tonometer)was used to measure the intraocular pressure for 24h with 24 patients(48 eyes)who were measured for 48h at 7:00, 10:00, 14:00, 18:00, 22:00, 02:00, 05:00 from July to August in 2019 in the department of Ophthalmology, Jiaxing Hospital of Traditional Chinese Medicine, Intraocular pressure measurements in sitting and lying positions were performed at 22:00, 2:00, and 5:00. Intraocular pressure measurements in lying positions were measured at first. Then the patients were required to remain the sitting position for 10min, and measured the intraocular pressure in sitting positions again. Repeated measurements were used in the intraclass correlation coefficient(ICC)within-group to analyze consistency. The intraocular pressure of different body positions at night was analyzed and compared with the paired t test.

RESULTS: The ICC value at each time point fluctuates between 0.79-0.94, most of which are around 0.90 and both eyes are basically the same. The ICC values in the night time decubitus position fluctuated from 0.73 - 0.91, mostly above 0.86. The ICC value at each time point was above 0.75, most of which was around 0.90 which shows the consistency of repeated intraocular pressure measurements at each time point is good. However, the ICC results of intraocular pressure fluctuations were poor. The ICC value of the right eye was 0.49 and the left eye was 0.55. The ICC value of the right eye in lying positions was 0.40 and the left eye was 0.43. The consistency of the right eye was poor. The intraocular pressures in lying positions at night were higher than that in the sitting position, which was a difference at all time points.

CONCLUSION: A single 24h intraocular pressure measurement may not be highly reproducible, especially for intraocular pressure fluctuations. The reliability of the results of one measurement needs to be studied. The intraocular pressure measurement in the sitting position at night may not represent the actual intraocular pressure during sleep at night.