AIM: To investigate the efficacy of a new self-crosslinking sodium hyaluronate(Qianchuangfu)on the healing and epithelization at the ostium of dacryocyst flap and nasal mucosal flap after endoscopic endonasal dacryocystorhinostomy(EE-DCR), so as to improve the curative effect of EE-DCR.

METHODS: A prospective randomized controlled study. A total of 135 patients(146 eyes)diagnosed as chronic dacryocystitis from May 2020 to April 2021 in our hospital were enrolled. All patients underwent EE-DCR. According to the principle of double-blind random sampling, they were divided into three groups before surgery. Group A: Qianchuangfu was used to filling the ostium at the end of surgery. Group B: Tobramycin and Dexamethasone eye ointment was used to filling the ostium at the end of surgery.Group C:blank control group. All patients were followed up to 3mo after surgery.

RESULTS: Excluding 7 patients(8 eyes)with incomplete follow-up data, 128 patients(138 eyes)were included in the comparative analysis, including 47 eyes in group A, 45 eyes in group B and 46 eyes in group C. The ostium epithelization in group A was significantly better than that in group B and group C at 1, 2wk and 1mo after surgery(all P<0.017). At 3mo after surgery, the success rate of group A, group B and group C was 95.7%(45/47), 82.2%(37/45)and 73.9%(34/46), respectively. The curative efficacy of group A were significantly higher than that of group B and group C(all P<0.017).

CONCLUSION: Ostium filling with Qianchuangfu at the end of EE-DCR can effectively promote wound healing and epithelization around the ostium,so as to improve the efficacy of EE-DCR in the treatment of patients with chronic dacryocystitis.