角膜滞后量在青光眼中的作用
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黑龙江省自然科学基金项目(No.LH2020H041); 哈尔滨医科大学附属第一医院科研创新基金项目(No.2020M23)


Role of corneal hysteresis in glaucoma
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Natural Science Foundation of Heilongjiang Province(No.LH2020H041); Scientific Research and Innovation Foundation of the First Affiliated Hospital of Harbin Medical University(No.2020M23)

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    摘要:

    青光眼是全球首位不可逆致盲性眼病,其具体发病机制尚不清楚,但颇受重视的是眼压和房水流出通道等方面。近年,研究人员开始越来越多地关注非压力依赖因素如角膜滞后量(CH)在青光眼中的作用。CH是角膜的生物力学参数,它反映了角膜的黏性阻力,即吸收和分散能量的能力。CH在临床上很容易获得,可作为眼后部组织生物力学特性的替代标志物,如筛板和乳头周围巩膜,这些组织可能与青光眼损伤的易感性有关。有研究提供了CH与青光眼临床相关结果之间的联系的证据。本文综述了CH在青光眼中的作用的最新发现,从CH的测量方法、CH与中央角膜厚度、青光眼性视野进展、视盘损害、视网膜神经纤维层缺失等方面进行了归纳和总结。

    Abstract:

    Glaucoma is a leading cause of irreversible blindness in the world and its specific pathogenesis is not clear. More attention has been paid to intraocular pressure and aqueous outflow channel. In recent years, scholars began to attach more importance to the role of non-pressure dependent factors, such as corneal hysteresis(CH), in glaucoma. CH is a biomechanical parameter of cornea, which reflects the viscous resistance of cornea, i.e., the ability to absorb and disperse energy. CH can be easily acquired clinically and may serve as surrogate markers for biomechanical properties of tissues in the back of the eye, like the lamina cribrosa and peripapillary sclera, which may be related to the susceptibility of glaucomatous damage. Several studies have provided evidence of the associations between CH and clinically relevant outcomes in glaucoma. This article reviews the latest findings on CH and summarizes the measurement methods of CH, relations between CH and central corneal thickness, glaucomatous visual field progress, optic disc damage, retinal nerve fiber layer loss, etc.

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罗茜,张春巍.角膜滞后量在青光眼中的作用.国际眼科杂志, 2022,22(12):2001-2004.

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  • 收稿日期:2022-01-24
  • 最后修改日期:2022-11-08
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  • 在线发布日期: 2022-11-29
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