AIM: To analyze the relationship between ocular signs and quality of life in patients with thyroid-associated ophthalmopathy(TAO).

METHODS:A total of 356 patients with TAO who treated at a general hospital in Chengdu from October 2019 to December 2019 were selected. Their basic information and ocular signs(intraocular press, visual acuity, exophthalmos and eyelid retraction)were collected. In addition, the Graves Ophthalmopathy Quality of Life Scale(GO-QOL)was used to evaluate patients' quality of life.

RESULTS:The median of visual function and social psychology of patients with TAO were 87.50 and 68.75 respectively. It was indicated that TAO patients' visual function scores were related to intraocular pressure, visual acuity and eyelid retraction(all P<0.05), social psychology scores were related to visual acuity(P<0.05), the high intraocular pressure had a significant influence on patients' visual function scores(P=0.001), and different visual acuity had a significant influence on the social psychology scores of patients with TAO(P=0.012).

CONCLUSION:High intraocular pressure and impaired vision can reduce TAO patients' quality of life. Hence, medical staff should pay attention to the ocular signs during symptom management, especially the high intraocular pressure and low visual acuity, actively treating and preventing adverse ocular signs, so as to improve the quality of life of patients with TAO.