目的：观察0.005%阿托品滴眼液联合角膜塑形镜控制不同民族青少年低度近视的有效性、安全性及民族差异性。

方法：选取2021-01/10就诊于我院的汉族、哈尼族低度近视患者246例246眼，其中试验组患者120例120眼采用0.005%阿托品滴眼液联合角膜塑形镜治疗； 对照组患者126例126眼采用角膜塑形镜治疗。观察两组患者戴镜前、戴镜1 a的裸眼视力、等效球镜度(SE)、眼轴长度(AL)、眼压、泪膜破裂时间(BUT)、角膜曲率、角膜厚度，记录两组患者并发症发生情况。

结果：戴镜1 a，试验组患者AL和SE变化量(0.16±0.35 mm、-0.39±0.47 D)低于对照组(0.22±0.89 mm、-0.48±0.54 D)，裸眼视力(LogMAR)优于对照组(0.11±0.25 vs 0.14±0.19 )(P<0.05)，BUT、前房深度、角膜曲率及角膜厚度均有差异(P<0.05)，但两组患者眼压无差异(P>0.05)，且两组中汉族和哈尼族患者裸眼视力、AL及SE变化量比较均无差异(P>0.05)。随访期间，两组患者均未出现明显的局部及全身不良反应，两组患者眼部并发症发生率均无差异(P>0.05)。

结论：0.005%阿托品滴眼液联合角膜塑形镜可有效延缓青少年低度近视进展，且无明显不良反应及民族差异性。

METHODS:A total of 246 Han and Hani patients(246 eyes)with low myopia treated in our hospital from January to October 2021 were selected, with 120 patients(120 eyes)treated with 0.005% atropine eye drops combined with orthokeratology in experimental group, and 126 patients(126 eyes)treated with orthokeratology in control group. The uncorrected visual acuity, spherical equivalent(SE), axial length(AL), intraocular pressure, tear film break-up time(BUT), corneal curvature and corneal thickness of the two groups before and 1 a after wearing lenses were observed, and the incidence of complications were recorded.

RESULTS:At 1 a after wearing lenses, the changes of AL and SE in the experimental group(0.16±0.35 mm, -0.39±0.47 D)were lower than those in the control group(0.22±0.89 mm, -0.48±0.54 D), uncorrected visual acuity(LogMAR)was better than the control group(0.11±0.25 vs 0.14±0.19; P<0.05), there were differences in BUT, anterior chamber depth, corneal curvature and corneal thickness(P<0.05), but there were no differences in intraocular pressure of the two groups(P>0.05). In the Han and Hani groups, there were no differences in the changes of uncorrected visual acuity, AL and SE(P>0.05). During the follow-up period, no significant local or systemic adverse reactions occurred in the two groups, and there was no difference in the incidence of ocular complications between the two groups of patients(P>0.05).

CONCLUSION: The 0.005% atropine eye drops combined with orthokeratology can effectively delay the progression of low myopia in adolescents without significant adverse reactions and ethnic differences.