酮体代谢在糖尿病视网膜病变(Diabetic Retinopathy,DR)发生发展中发挥重要作用。既往研究发现脂代谢紊乱与DR发展密切相关,酮体作为糖代谢受阻时,脂肪分解的代谢产物,其主要包括β-羟丁酸、乙酰乙酸和丙酮。研究发现,酮体代谢与DR的多个病理生理过程密切相关,如视网膜细胞的氧化应激、炎症反应和神经细胞变性等。本文通过探讨酮体代谢对DR发病机制产生的影响进行综述。

Ketone body metabolism plays a significant role in the development and progression of Diabetic Retinopathy (DR). Previous research has established a close relationship between dyslipidemia and DR progression. Ketone bodies, comprising β-hydroxybutyrate, acetoacetate, and acetone, are metabolic products generated from fat breakdown when glucose metabolism is impaired. Studies have revealed that ketone body metabolism is intricately linked to multiple pathophysiological processes in DR, including oxidative stress, inflammatory responses, and neurodegeneration within retinal cells. This article provides a review exploring the impact of ketone body metabolism on the pathogenesis of DR.

α-Klotho通过UPS改善巨噬细胞衰老在DR中保护作用研究(82360209)