目的：比较ARK Biometer Combo与OA 2000在配戴角膜塑形镜患者中生物测量的一致性。方法：前瞻性研究。选取2024年8月～2024年9月至上海市眼病防治中心配戴角膜塑形镜的复诊患者148例（148眼），分别应用ARK Biometer Combo和OA 2000进行生物测量，获得眼轴长度（AL）、角膜厚度（CCT）、前房深度（ACD）、晶状体厚度（LT）、角膜曲率（Kf和Ks）、散光（AST）、角膜横径（WTW）、瞳孔直径（PD)等参数。2 种仪器测量参数差异比较采用配对t检验，一致性评估采用组内相关系数（ICC）及采用Bland-Altman法。结果：2 种仪器测量Kf、Ks、AST的差异均无统计学意义（P＞0.05），测量AL、CCT、ACD、LT 、WTW及PD的差异有统计学意义（t=2.559，P=0.012； t=16.771，P＜0.0001；t=4.749，P＜0.0001；t=-15.212，P＜0.0001；t=-14.915，P＜0.0001；t=-2.402，P=0.018）。2 种仪器各测量参数的ICC为0.615～0.999。Bland-Altman分析显示2 种仪器测量AL、CCT、ACD、LT、Kf、Ks、AST、WTW及PD的95%一致性界限（LoA）最大绝对值分别为：0.07 mm、35.07 um、0.07 mm、0.12 mm、0.66 D、1.14 D、1.00 D、0.76 mm、0.98 mm。结论：在配戴角膜塑形镜患者中，ARK Biometer Combo和OA 2000 测量AL、CCT、ACD、Kf、LT的一致性好，可以相互替换使用。

Objective: To compare the agreement between the ARK Biometer Combo and OA 2000 in patients wearing orthokeratology lenses. Methods: A prospective study. A total of 148 patients (148 eyes) who were wearing orthokeratology lenses and returned for follow-up at the Shanghai Eye Disease Prevention and Treatment Center from August to September 2024 were included. Biometric measurements were performed using both the ARK Biometer Combo and OA 2000. Parameters including axial length (AL), corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), corneal curvature (Kf and Ks), astigmatism (AST), white-to-white corneal diameter (WTW) and pupil diameter (PD) were obtained. Differences in measurement parameters between the two biometers were compared using paired t-tests, and agreement was assessed using intraclass correlation coefficients (ICC) and Bland-Altman analysis. Results: There were no statistically significant differences in the measurements of Kf, Ks and AST between the two biometers (P > 0.05). Statistically significant differences were found in the measurements of AL, CCT, ACD, LT, WTW and PD (t = 2.559, P = 0.012; t = 16.771, P < 0.0001; t = 4.749, P < 0.0001; t = -15.212, P < 0.0001; t = -14.915, P < 0.0001; t = -2.402, P = 0.018). ICC ranged from 0.615 to 0.999. Bland-Altman analysis showed that the maximum absolute values of the 95% limits of agreement (LoA) of AL, CCT, ACD, LT, Kf, Ks, AST, WTW and PD were 0.07 mm, 35.07 μm, 0.07 mm, 0.12 mm, 0.66 D, 1.14 D, 1.00 D, 0.76 mm and 0.98 mm, respectively. Conclusion: In orthokeratology patients, the ARK Biometer Combo and OA 2000 showed good agreement in measuring AL, CCT, ACD, Kf and LT, and can be used interchangeably. Keywords: Biometry; ARK Biometer Combo; OA 2000; Myopia; Orthokeratology lenses