间歇性外斜视(Intermittent exotropia，IXT)是儿童最常见的斜视，中国人群中发病率约3.26%[1]，患者可短暂控制正位，但斜视度波动显著，在疲劳或注意力不集中时甚至自发外斜，未经任何治疗的间歇性外斜视约75%病情会进展[2]。其治疗分为手术治疗和非手术治疗。手术治疗是IXT最有效的治疗方法，但手术时机的选择一直存在争议，且存在术后欠矫、过矫，需要二次或多次手术可能[3]；非手术治疗包括观察、矫正屈光不正、负镜过矫、三棱镜治疗、正位视训练及肉毒杆菌毒素A的注射等，尤其适用于年幼、检查欠配合、斜视度数小、控制良好、不愿或想推迟手术的患者[4]，部分小度数间歇性外斜视可通过非手术治疗控制双眼正位和恢复双眼单视功能，推迟或避免手术。上述各个方法的疗效不一，本文旨在对间歇性外斜视非手术治疗的研究进展作一综述。

Intermittent exotropia (IXT) is the most prevalent form of childhood strabismus ,with an estimated prevalence of approximately 3% in the Chinese population [1]. Although patients can intermittently maintain orthotropia,the deviation angle often fluctuates markedly,and frank exotropia may become evident during fatigue or lapses in attention.Without intervention ,roughly 75% of cases progress over time[2]. Management comprises surgical and non-surgical approaches. Surgery remains the most definitive treatment,however,the optimal timing is controversial, and postoperative outcomes may include under- or over-correction, necessitating additional procedures[3].Non-surgical options include observation, refractive correction,over-minus lens therapy, prisms, orthoptic exercises, and botulinum toxin-A injections. These modalities are particularly suitable for young, or uncooperative children,patients with small-angle,well-controlled deviations,or those seeking to defer surgery[4],in such cases,non-surgical treatment can maintain binocular alignment and preserve monocular function,thereby delaying or avoiding surgery. Because the efficacy of each non-surgical strategy varies,this review summarises the current evidence on non-surgical treatment of intermittent exotropia.