Abstract:Vision is closely related to quality of life with age-related macular degeneration, glaucoma, and diabetic retinopathy commonly happening. Clinical treatment tends to use less invasive topical administration and systemic administration. Many physiological and biochemical obstacles in the eye, including tear film turnover, corneal penetration, blood-ocular barrier and so on, limit the penetration and distribution of drugs in the eye, resulting in low bioavailability of drugs and affecting the clinical drugs efficacy. Due to the difficulty of sampling, the pharmacokinetic characteristics of drugs in the human eye are still unclear. Therefore, establishing an ocular compartment model, typically considering the cornea or vitreous as the central compartment and treating other ocular tissues as the peripheral compartment, can simulate and study the drug exposure in the eye, which helps predict the bioavailability and therapeutic effect of drugs in the eye. Based on this, developing a physiologically-based pharmacokinetic model, which includes factors like changes in ocular blood flow, transporter effects on drug transport, blood-retinal barrier, blood-aqueous barrier, etc., can provide more details on the disposition of drugs in the eye, thereby assisting in the development of new ophthalmic drug and better treating eye diseases.