·AIM:To study the possible mechanism of uveitis by evaluating the expression of cytokines produced by peripheral blood mononuclear cells.·METHODS:Peripheral blood was drawn from 30 patients with uveitis and 20 normal people.After separation and short term culture of the mononuclear cells,the amount of IFN-γ,TNF-α and IL-10 in the supernatant were evaluated respectively with ELlSA.·RESULTS:The amount of IFN-γ and TNF-α produced by peripheral blood mononuclear cells from the patients were much higher than that in the normal people(P<0.05),and they both correlated well with disease activity of uveitis.IL-10 expression in that of uveitis was little higher than normal control with no statistical significance.·CONCLUSION:The elevated expression of IFN-γ and TNF-α by peripheral blood mononuclear cells may play important role in the pathogenesis of uveitis.·